Related Papers
ANTIDEPRESSANT EFFECT OF ZIZIPHUS MAURITANIA AGAINST FORCED SWIM TEST INDUCED DEPRESSION IN WISTAR RATS
Editor iajps
Chronic stress increases disease susceptibility to depression and other neurodegenerative disorders. Depression is characterized by disturbances in emotions, cognition, autonomic and endocrine functions affecting 21% of the world's population. The present investigation aimed to explore the antidepressant effect of ethanolic extract of Ziziphus Mauritania (EEZM) against forced swim test induced depression in wistar rats. Rats were administered with EEZM in the doses of 200mg/kg and 400mg/kg daily orally and subjected to forced swim test. The study is carried out for 14 days. EEZM administration reduced the immobility duration in forced swim test. Neurobehavioural alterations were assessed using elevated plus maze and open field exploration and treatment with EEZM averted behavioural despair. Increased TBARS level and decreased antioxidant enzymes such as SOD, Gpx and Catalase levels due to stress were observed. Administration with EEZM reversed all these deleterious effects and raised SOD, Gpx and Catalase levels. Thus the present observation indicates the antidepressant activity of EEZM. Further neurochemical and molecular studies would unravel the possible mechanisms involved in antidepressant activity of EEZM.
Nepal Journal of Health Sciences
Anti-depressant Activity of the Seeds of Zanthoxylum armatum on Swiss Albino Mice
Chandrajeet Kumar Yadav
Introduction: Depression disorder has significant potential morbidity and mortality, contributing to suicide, incidence and adverse outcomes of medical illness, disruption in interpersonal relationships, substance abuse, and lost work time. Objectives: The present study was designed to study the anti-depressant activity of the seeds extract of Zanthoxylum armatum using a forced swim test and tail suspension test on Swiss albino mice. The anti-depressant activity of the seeds of Zanthoxylum armatum was assessed using Chronic Unpredictable Mild-Stress (c*ms) induced depression in mice. Methods: The animals were treated with the methanolic extract of seeds of Zanthoxylum armatum orally at two doses of 100, 200mg/kg body weight for eight days after c*ms induced depression in mice. The results demonstrate that Methanolic extract of seeds of Zanthoxylum armatum has got anti-depressant potential. Results: The study showed that the extract of Zanthoxylum armatum had significant antidepressa...
Methanol Aerial Parts Extract of Caralluma Dalzielii (Asclepiadaceae) Possessed In-Vivo Antidepressant Activity in Mice
2020 •
suleiman yunusa
Though Caralluma dalzielii N.E Br (Asclepiadaceae) is widely used traditionally for treating nervous system disorders, there is an absence of scientific reports about its pharmacological effect against depression. In this work, the potential antidepressant effects of the methanol extract of the aerial parts of Caralluma dalzielii were evaluated in mice using behavioral models (tail suspension and forced swimming tests) sensitive to clinically effective antidepressant agents. The extract at the doses of 10, 20 and 40 mg/kg body weight (intraperitonially) was able to significantly (p< 0.05) decrease the immobility time of mice in a non-dose dependent and dose dependent manner when subjected to both tail suspension and forced swimming tests respectively and the effects were comparable to the effect produced by the standard drug imipramine (10mg/kg). It can be concluded that the present work suggested that methanol extract of the aerial parts of Caralluma dalzielii possessed potentia...
2---APP-553-22-05-15 Sci-Revised-27-6-15+
praveen kumar
Avicenna Journal of Phytomedicine
Evaluation of antidepressant-like effects of aqueous and ethanolic extracts of Pimpinella anisum fruit in mice
2016 •
Saeid Abbasi Maleki
Objective: Pimpinella anisum (P. anisum) has different pharmacological properties such as anticonvulsant, analgesic, tranquilizer, antidepressant and anti-anxiety effects. In this study the antidepressant-like effect of aqueous and ethanolic extracts of P. anisum fruit in mice was investigated. Materials and Methods: Forced swimming test (FST) and tail suspension test (TST) were used to determine the antidepressant effects of P. anisum (50, 100 and 200 mg/kg, i.p.) fruit extracts. Fluoxetine (20 mg/kg, i.p.) and imipramine (30 mg/kg, i.p.) were used as standard drugs. Results: All the three doses of aqueous and ethanolic extracts (except 50 mg/kg of aqueous extract in FST) significantly and dose-dependently reduced the immobility times in both FST and TST. All doses of extracts increased the swimming time dose-dependently, without any significant change in climbing time. In addition, all doses of ethanolic extract reduced immobility times and increased swimming time insignificantly ...
STUDY OF NEUROPROTECTIVE ACTIVITY OF METHANOLIC EXTRACT OF OXALIS CORNICULATA LINN ON ANIMAL MODELS OF DEPRESSION
IJESRT Journal
Depression and anxiety disorders are the most common mental illnesses, each affecting in excess of 10-15% of the population at some time in their lives. Approximately 450 million people suffer from a mental or behavioural disorder according to the WHO report, resulting in 12.3% of the global burden of disease. Though various therapeutic regimens are used to treat anxiety and depressive disorders; but due to their side effects and dependence liability their use in clinical practice is limited. Research studies on different medicinal plants in various animal models has widely contributed in the search of new therapeutic products for the treatment of various neurological disorders. Hence the present study was undertaken to evaluate the neuroprotective activity of Methanolic extract of Oxalis corniculata Linn on animal models of depression.
A Cognitive Approach to Translation of Conceptual Metaphors in Documentary Films
2011 •
Ghasem Vadipoor
The present paper favors a cognitive approach to metaphor launched by Lakoff and Johnson’s influential book, Metaphors We Live By (1980). The aim of the study is to identify the aspects of similarities and differences of conceptual expressions between the source and target languages, and try to explore the translation strategies used by the translators based on the most outstanding translation hypothesis proposed by Kovecses (2005). The corpus comprises two collections of documentary films which are nine hundred minutes altogether. The results obtained from the comparison of linguistic and cultural peculiarities of the metaphorical expressions between the two languages revealed that similarities in metaphorical expressions increase translatability, while differences hinder the translation process. The analysis also showed that the translators tended to copy the original and reproduce in the TT the same image as given in the ST. It seemed that the tendency towards isomorphism is resu...
Advances in Pharmacology and Pharmacy
Bacopa monnieri (Linn.) Pennell -A Possible Plant for Impossible Diseases (A Review
2022 •
Abhishek kumar Pandey
Since the beginning of humankind, people are using numerous plants to cure diseases and abnormalities. Bacopa monnieri has been used by people for a long time. This plant has several medicinal and biochemical properties which would be beneficial to treat diseases. The current review article summarizes the medicinal, presence of the bioactive compound, mechanism of action, therapeutic importance, clinical trials, ethnobotanical usage, and distribution of the plant with respect to India and worldwide. Relevant information and literature on Bacopa monnieri were extracted from different sources and their finding were discussed in the manuscript. The number of therapeutic properties of the plant has been seen in the animal model experiment including anti-diarrheal, antioxidant, anti-inflammatory, anti-cancer, anti-fungal, anti-bacterial, anti-convulsant, hepatoprotective, antiulcer, anti-depressant, anti-hyperglycemic and anti-nociceptive activity, immunostimulatory activity, and wound healing activity. This article recapitulates ethnopharmacological uses of Bacopa monnieri to explore its therapeutic potentials thereby providing a basis for future research. Bacopa monnieri exhibits a comprehensive of pharmacological activities that could be observed by the presence of a vast range of chemical constituents. Manuscript also comprises tissue culture techniques and propagation of Bacopa monnieri. The study also provides a descriptive outlook on the uses of Bacopa monnieri in wastewater treatment. This review article highlights the endless possibilities present in the plant and also sheds light on research that has not yet been done on this plant and may prove useful if done in the future.
Tropical Journal of Natural Product Research
Involvement of Anti-Inflammatory Mechanism in the Antidepressant Activity of Methanol Stem Bark Extract of Adansonia digitata L. (Malvaceae)
2019 •
Sagir Mustapha
International Journal of Pharma Research and Health Sciences
Anxiolytic Antidepressant and Anti-Inflammatory Activity of Ethanolic Extract of Urena Lobata Leaf
2016 •
Bindu Madhuri
